5AMINO-1MQ Tablets 40mg x 25

5-Amino-1MQ Research Tablet – 40mg NNMT Inhibitor (RUO) 5-Amino-1MQ: Widely Studied Substrate for Metabolic and Cellular Energy Research This 5-Amino-1MQ research tablet supplies 40mg per tablet, with 25 tablets per bottle, for non-clinical laboratory use. 5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme examined in preclinical research for its role in metabolic regulation, NAD availability, and adipocyte function. NNMT activity is highly expressed in adipose tissue, where research models examine its influence on cellular energetics and downstream metabolic pathways. Preclinical research models examining NNMT inhibition by 5-Amino-1MQ have assessed: Intracellular NAD availability in metabolic models Metabolic-rate modulation in adipocyte studies SIRT1 pathway activity and NAD -dependent signaling Adipocyte morphology in experimental diet models Methylation-cycle flux and SAM/SAH pathway regulation This product is intended strictly for Research Use Only (RUO). Not for human consumption. 5-Amino-1MQ Research Tablet — Biochemical Overview NNMT Inhibition and Metabolic Pathway Research The 5-Amino-1MQ research tablet is a selective, membrane-permeable small-molecule inhibitor of NNMT. Research models assess 5-Amino-1MQ activity across: NNMT-linked methylation and one-carbon metabolism pathways NAD precursor availability and sirtuin-pathway signaling Adipose tissue metabolic flux in high-fat-diet models Cellular energy-balance regulation in metabolic assays Tissue-specific NNMT expression patterns Cellular Energy and NAD Research Research models examining the 5-Amino-1MQ research tablet alongside NAD pathway substrates assess interactions between NNMT inhibition and mitochondrial function. Oxidative phosphorylation efficiency and NAD -dependent enzyme activity are additional areas examined in cellular models using 5-Amino-1MQ as the primary substrate. Research Specifications Attribute Specification Product Name 5-Amino-1MQ Research Tablet Strength 40mg per tablet Quantity 25 tablets per bottle Category Oral Research Compounds Use Research Use Only (RUO) Intended Users Qualified laboratory professionals General Laboratory Considerations Store in a cool, dry environment Protect from light and moisture Use only in controlled laboratory settings Not for human or veterinary use Representative Literature The following publications provide scientific context on 5-Amino-1MQ and NNMT inhibitor research. These works do not involve Novaglo Research products and are included solely to support background understanding of metabolic-enzyme biology. Selective NNMT Inhibitors and Metabolic Regulation Neelakantan H. et al. Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. Biochemical Pharmacology. 2018;147:141-152. This study characterizes selective NNMT inhibitors including 5-Amino-1MQ in high-fat-diet models, examining methylation-cycle modulation and metabolic-flux regulation in adipose tissue. NNMT Expression and Adipose Tissue Metabolism Kraus D. et al. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014;508(7495):258-262. This foundational study examines NNMT’s role in adipose tissue metabolic regulation, establishing NNMT as a key substrate in energy-balance pathway research. NAD Pathway Interactions and Sirtuin Signaling Eckert M.A. et al. Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts. Nature. 2019;569(7758):723-728. This publication characterizes NNMT’s broader role in cellular metabolic regulation, including NAD availability and one-carbon metabolism, providing context for 5-Amino-1MQ pathway research. Small-Molecule NNMT Inhibitor Cellular Mechanisms Campagna R. et al. NNMT inhibition produces cell-based and in vivo anti-obesity effects. Cell Chemical Biology. 2024. This study assesses NNMT inhibitor activity in cellular and in vivo models, examining metabolic-rate modulation and adipocyte function relevant to 5-Amino-1MQ research applications. This product is not a drug, supplement, or therapeutic agent. It is not for human consumption and is intended solely for laboratory research by qualified professionals. No medical, diagnostic, or therapeutic claims are made or implied. For research use only. Not for human consumption.